Founded in 2003, the University of Luxembourg is the only university in the Grand Duchy of Luxembourg. It was set up as a multilingual and international institution and is strongly focused on research. The Luxembourg Centre for Systems Biomedicine (LCSB) is accelerating biomedical research by closing the link between systems biology and medical research. Collaboration between biologists, medical doctors, computer scientists, physicists, engineers and mathematicians is offering new insights in complex systems like cells, organs, and organisms. These insights are essential for understanding principal mechanisms of disease pathogenesis and for developing new tools in diagnostics and therapy. Neurodegenerative diseases like Parkinson’s disease and description of diseases as networks are at the focus of LCSB’s research. The Centre has established strategic partnerships with leading biomedical laboratories worldwide and with all major biological and medical research units in Luxembourg. The LCSB fosters collaboration with industrial partners and promotes the translation of fundamental research results into (clinical) applications.